p53 regulation · proteogenomics · biologics
Hupp Lab
The University of EdinburghWelcome to our lab
Hupp Lab
The Hupp laboratory studies how p53 and other cancer-associated proteins are controlled by modification, conformation and dominant oncogenic interactions, then translates that knowledge into biomarkers, biologics and drug-discovery strategies.
Principal investigator
Edward (Ted) Hupp, PhD
Chair of Cancer Research
The Hupp laboratory studies how p53 and other cancer-associated proteins are controlled by modification, conformation and dominant oncogenic interactions, then translates that knowledge into biomarkers, biologics and drug-discovery strategies.
View official profile →Research programmes
Four connected research programmes
01
p53 structure, modification and activation
How is p53 converted from a restrained protein into an active tumour suppressor?
02
Oncogenic protein interactions that suppress p53
Which dominant oncogenic signals disable p53 without mutating TP53?
03
Cancer proteogenomics and neoantigen discovery
How can tumour sequence variation be translated into actionable protein information?
04
Next-generation biologics and drug discovery
Can mechanistic target knowledge be converted into selective biologics and small molecules?
Selected publications
Recent and defining work
2025↗2025↗2020↗2012↗2010↗
Functional characterisation of TIM3-directed antibodies
Antibody therapeutics
DoggifAI: interpretation of cancer-associated protein variation
Computational oncology
High-content phenotypic profiling of oesophageal adenocarcinoma models
Scientific Reports
Nanosensing of the p53–MDM2 protein interaction
Biosensors and Bioelectronics
Regulation of p53 through phosphorylation at Ser269
Journal of Biological Chemistry
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